Related Experiment Video
Updated: Jun 15, 2025
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Cardiovascular disease and covid-19: A systematic review
B A Krishna1, M Metaxaki1, N Sithole1,2
1Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Insights
COVID-19 causes numerous cardiovascular complications, including heart attacks and arrhythmias. These issues can persist, contributing to Long COVID symptoms and impacting long-term cardiovascular health.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Cardiovascular complications associated with COVID-19 are extensive and not fully understood.
- The virus SARS-CoV-2 can lead to a wide range of cardiac issues.
Purpose of the Study:
- To conduct a systematic review of acute and chronic cardiovascular complications following COVID-19 infection.
- To consolidate current knowledge on the cardiac sequelae of COVID-19.
Main Methods:
- A systematic literature review was performed using the Medline database via PubMed.
- The review encompassed studies published between 2020 and 2024.
Main Results:
- COVID-19 presents numerous acute cardiovascular effects, including myocardial injury, myocarditis, arrhythmias, heart failure, and Takotsubo cardiomyopathy.
- These acute cardiac injuries can persist, potentially underlying some symptoms of Long COVID.
- Pathophysiological mechanisms linking SARS-CoV-2 infection to cardiac damage are discussed.
Conclusions:
- Cardiovascular complications of COVID-19 are significant and potentially life-threatening.
- Long COVID may involve persistent cardiovascular dysfunction.
- Targeting SARS-CoV-2-induced microclotting presents a potential therapeutic avenue for Long COVID's cardiovascular manifestations.
Background:
Cardiovascular complications of COVID-19 are numerous and aspects of this phenomenon are not well known. The main objective of this manuscript is a systematic review of the acute and chronic cardiovascular complications secondary to COVID-19.
Methods:
A systematic review of the literature through Medline via PubMed was conducted (2020-2024).
Results:
There is a plethora of effects of COVID-19 on the heart in the acute setting. Here we discuss pathophysiology, myocardial infarctions, heart failure, Takotsubo Cardiomyopathy, myocardial injury, myocarditis and arrhythmias that are caused by COVID-19. Additionally, these cardiovascular injuries can linger and may be an underlying cause of some Long COVID symptoms.
Conclusions:
Cardiovascular complications of COVID-19 are numerous and life-threatening. Long COVID can affect cardiovascular health. Microclotting induced by SARS-CoV-2 infection could be a therapeutic target for some aspects of Long Covid.
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