Related Experiment Video
Updated: Jun 15, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Cardiovascular disease and covid-19: A systematic review
B A Krishna1, M Metaxaki1, N Sithole1,2
1Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Background:
Cardiovascular complications of COVID-19 are numerous and aspects of this phenomenon are not well known. The main objective of this manuscript is a systematic review of the acute and chronic cardiovascular complications secondary to COVID-19.
Methods:
A systematic review of the literature through Medline via PubMed was conducted (2020-2024).
Results:
There is a plethora of effects of COVID-19 on the heart in the acute setting. Here we discuss pathophysiology, myocardial infarctions, heart failure, Takotsubo Cardiomyopathy, myocardial injury, myocarditis and arrhythmias that are caused by COVID-19. Additionally, these cardiovascular injuries can linger and may be an underlying cause of some Long COVID symptoms.
Conclusions:
Cardiovascular complications of COVID-19 are numerous and life-threatening. Long COVID can affect cardiovascular health. Microclotting induced by SARS-CoV-2 infection could be a therapeutic target for some aspects of Long Covid.
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