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Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome
Johannes Pawlowski1, Tatsiana Pukhalskaya2, Kelly Cordoro3
1Department of Dermatology, University Hospital Mainz, 55131 Mainz, Germany.
Dermatopathology (Basel, Switzerland)
|August 27, 2024
Summary
Netherton syndrome (NS) involves skin barrier dysfunction and inflammation. Interleukin-36 (IL-36) immunostaining shows promise as a diagnostic tool for this rare genetic disorder.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Netherton syndrome (NS) is a rare autosomal recessive disorder caused by SPINK5 mutations.
- NS leads to impaired skin barrier function and significant inflammation.
- The exact inflammatory pathways in NS are not fully understood, but IL-17/IL-36 and Th2 cytokines are implicated.

