Association between Regular Use of Analgesics before Cancer Diagnosis and Occurrence of Mood Disorders
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View abstract on PubMed
Summary
This summary is machine-generated.Regular use of analgesics is linked to a higher risk of developing mood disorders, especially in cancer survivors. Physical activity may help prevent mood disorders in older patients.
Area Of Science
- Psychiatry
- Oncology
- Pharmacology
Background
- Mood disorders pose a significant public health challenge.
- Analgesic use is common for pain management, but its long-term effects on mental health are not fully understood.
Purpose Of The Study
- To investigate the association between analgesic use and the risk of developing mood disorders.
- To identify risk factors for mood disorder onset in a large cohort.
Main Methods
- Utilized a large-scale cohort database to analyze patient data.
- Employed proportional hazards regression models to calculate hazard ratios (HR) with 95% confidence intervals (CI).
- Adjusted for multiple variables including age, income, BMI, physical activity, and comorbidities.
Main Results
- Regular analgesic use was associated with a significantly higher risk of mood disorders (HR = 1.698).
- Non-regular use also showed an increased risk (HR = 1.386).
- Among patients over 50, physical activity (less than five days/week) was linked to a lower risk of mood disorders.
Conclusions
- High comorbidity burden and regular analgesic use are identified as risk factors for mood disorders.
- Cancer survivors with high comorbidity risk and regular analgesic use may benefit from psychiatric consultation.
- Physical activity could play a role in mood disorder prevention among older cancer survivors.
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