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A Gd(III)-labelled self-assembling peptide as a potential pH-responsive MRI contrast agent
Carlo Martin M Ocampo1, Aaron Joseph L Villaraza1
1Institute of Chemistry, University of the Philippines Diliman, Philippines. alvillaraza@up.edu.ph.
Dalton Transactions (Cambridge, England : 2003)
|August 27, 2024
Abstract:
A marine-derived peptide labelled with a Gd(III)-chelate was found to self-assemble depending on the solution pH, accompanied by changes in T1-relaxivity (r1) values when in the dispersed or self-assembled form. Such pH-responsive behavior can be advantageous in the development of macromolecular magnetic resonance imaging (MRI) contrast agents which monitor the tissue physiology.
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