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piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...

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Updated: Jun 15, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

PlantCircRNA: a comprehensive database for plant circular RNAs.

Shutian He¹, Jianhao Bing¹, Yang Zhong¹

¹Agricultural Big Data Research Center, College of Information Science and Engineering, Shandong Agricultural University, Taian 271018, China.

Nucleic Acids Research

|August 27, 2024

Summary

This summary is machine-generated.

PlantCircRNA is a new database for plant circular RNAs (circRNAs), offering insights into these regulatory molecules. It consolidates data from numerous species and samples, aiding research into plant gene regulation.

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Last Updated: Jun 15, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

Molecular Biology
Genomics
Bioinformatics

Background:

Circular RNAs (circRNAs) are novel regulatory non-coding RNAs found in eukaryotes.
Research on plant circRNAs remains limited, despite their presence across plant species.

Purpose of the Study:

To establish a comprehensive database and resource for plant circRNAs.
To facilitate the study and understanding of circRNA functions in plants.

Main Methods:

Developed PlantCircRNA, integrating data from 94 plant species and 39,245 RNA-sequencing samples.
Incorporated existing AtCircDB and CropCircDB databases, manually curated circRNAs from literature.
Added tissue-specific and abiotic stress-related information for circRNAs.

Main Results:

PlantCircRNA provides a centralized repository for plant circRNA data.
Includes a detection score for circRNA consistency and a standardized naming system.
Offers a platform for data visualization, analysis, and download.

Conclusions:

PlantCircRNA serves as a valuable resource for the plant science community.
Enhances understanding of plant circRNAs and their regulatory roles.
Promotes further research into these non-coding RNAs in plants.