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Related Experiment Videos

Unexpected lambda chain expression in lymphocytic malignancy.

F Hecht, R Morgan, B K Hecht

    International Journal of Radiation Oncology, Biology, Physics
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Specific chromosome translocations are key to cancer development. This study identifies a novel sequence of these events in non-Hodgkin lymphoma and acute lymphocytic leukemia, linked to light chain expression.

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    Area of Science:

    • Cytogenetics
    • Oncology
    • Immunology

    Background:

    • Specific chromosome translocations are hallmarks in the development of lymphoid malignancies.
    • Translocations t(14;18) and t(2;8) are associated with non-Hodgkin lymphoma and acute lymphocytic leukemia (ALL), respectively.
    • Immunoglobulin light chain expression (kappa or lambda) is a critical cellular marker.