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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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TGF - β Signaling Pathway01:16

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Ttyh3 Promotes Cervical Cancer Progression By Activating The Wnt/-catenin Signaling Pathway.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Ttyh3 Promotes Cervical Cancer Progression By Activating The Wnt/-catenin Signaling Pathway.

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TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/-Catenin Signaling Pathway.

Xiuyan Huang1, Qing Li1, Xiaoxia Zheng1

  • 1Department of Gynaecology, Jinan Maternity and Child Care Hospital, Jinan, Shandong, P.R. China.

Cancer Investigation
|August 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Tweety homolog 3 (TTYH3) drives cervical cancer progression by promoting cell growth, migration, and invasion. Inhibiting TTYH3 shows promise for treating this cancer by suppressing tumor growth and activating key signaling pathways.

Keywords:
TTYH3Wnt/β-catenin signalingcervical cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The role of tweety homolog 3 (TTYH3) has been investigated in various cancers.
  • Previous studies explored TTYH3 in hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer.

Purpose of the Study:

  • To investigate the role and mechanism of TTYH3 in cervical cancer progression.
  • To determine the correlation between TTYH3 expression and patient prognosis in cervical cancer.

Main Methods:

  • Analysis of TTYH3 expression in cervical cancer tissues and cells.
  • Assessment of TTYH3's effects on apoptosis, proliferation, migration, and invasion.
  • Investigation of TTYH3's impact on epithelial-mesenchymal transition (EMT) and Wnt/β-catenin signaling.
  • In vivo studies involving TTYH3 knockdown to evaluate tumor growth inhibition.

Main Results:

  • TTYH3 was highly expressed in cervical cancer tissues and cells.
  • High TTYH3 expression correlated with poor prognosis.
  • TTYH3 reduced apoptosis, promoted proliferation, migration, and invasion.
  • TTYH3 enhanced EMT and activated Wnt/β-catenin signaling.
  • TTYH3 knockdown inhibited tumor growth in vivo.

Conclusions:

  • TTYH3 plays a significant role in promoting cervical cancer progression.
  • TTYH3 facilitates cervical cancer progression by activating the Wnt/β-catenin signaling pathway.
  • Targeting TTYH3 may represent a potential therapeutic strategy for cervical cancer.