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Updated: Jun 15, 2025

Isolation and Culture of Mouse Cortical Astrocytes

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

Astrocyte Development in the Rodent.

Yajun Xie^1,2, Corey C Harwell^1,2, A Denise R Garcia³

¹Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Advances in Neurobiology

|August 27, 2024

Summary

This summary is machine-generated.

Astrocyte development is crucial for nervous system function, yet poorly understood, especially during postnatal stages. This review highlights key principles of astrocyte development, informing synapse and circuit maturation.

Keywords:

Astrocyte Cell fate Glia Gliogenesis Morphogenesis

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Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

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Published on: February 17, 2016

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Astrocytes are vital glial cells supporting numerous nervous system functions, including synaptic modulation and neural repair.
Understanding astrocyte development is critical, as it lags behind neuronal and oligodendrocyte development.
Postnatal astrocyte development coincides with synapse and neural circuit formation, highlighting its importance.

Purpose of the Study:

To review foundational principles of embryonic and postnatal astrocyte development.
To emphasize the knowledge gap in postnatal astrocyte maturation.
To connect astrocyte development to synapse and circuit maturation.

Main Methods:

Literature review focusing on rodent studies.
Synthesis of existing knowledge on astrocyte development.
Highlighting key molecular and temporal aspects.

Main Results:

Astrocytes play essential roles in synapse formation, blood-brain barrier maintenance, and neural repair.
Embryonic astrocyte development is better understood than postnatal development.
Postnatal astrocyte maturation is a key period for circuit development.

Conclusions:

Further research into postnatal astrocyte development is essential for understanding neural circuit maturation.
Astrocytes are key players in nervous system plasticity and repair.
A comprehensive understanding of astrocyte development is needed to fully grasp nervous system function.