Related Experiment Video

Updated: May 5, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

9.9K

Assessment of Left Atrial Fibrosis by Cardiac Magnetic Resonance Imaging in Ischemic Stroke Patients Without Atrial

Jin Hean Koh1, Lincoln Kai En Lim1, Ying Kiat Tan1

  • 1Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore.

Journal of the American Heart Association
|August 27, 2024
PubMed

Insights

Left atrial fibrosis is more prevalent in patients with embolic stroke of undetermined source (ESUS) than in healthy individuals. This finding suggests left atrial fibrosis may contribute to the development of ESUS.

Area of Science:

  • Cardiology
  • Radiology
  • Neurology

Background:

  • Left atrial (LA) fibrosis is a marker of atrial cardiomyopathy.
  • LA fibrosis is linked to atrial fibrillation and ischemic stroke.
  • Understanding this link is crucial for identifying LA cardiomyopathy biomarkers.

Purpose of the Study:

  • To investigate the association between LA fibrosis and embolic stroke of undetermined source (ESUS).
  • To utilize cardiac magnetic resonance imaging (CMR) for quantifying LA fibrosis.
  • To explore LA fibrosis as a potential biomarker for LA cardiomyopathy.

Main Methods:

  • Systematic review of studies quantifying LA fibrosis in ESUS patients versus controls.
  • Meta-analysis of data from 7 studies involving 705 patients.
  • Studies were identified from inception to February 2024, following a registered protocol.

Main Results:

  • Patients with ESUS showed significantly higher LA fibrosis compared to healthy controls (MD, 5.71%).
  • LA fibrosis was also significantly higher in patients with atrial fibrillation versus controls (MD, 8.22%).
  • No significant difference in LA fibrosis was found between ESUS patients and atrial fibrillation patients (MD, -0.92%).

Conclusions:

  • A higher degree of LA fibrosis is present in ESUS patients compared to healthy individuals.
  • LA fibrosis may play a significant role in the pathogenesis of ESUS.
  • Further research should explore LA fibrosis as a biomarker for atrial cardiomyopathy and stroke risk in ESUS.
Abstract

Keywords:
acute strokeembolic strokeischemic strokemagnetic resonance imagingmodifiable risk factors for stroke

More Related Videos

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.3K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
542
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
564
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
500