Non-apoptotic cell death in osteoarthritis: Recent advances and future
Pengfei Ji1, Ziyu Zhou1, Jinyuan Zhang1
1The Second Clinical Medical College, Lanzhou University, No. 199 DongGang West Road, Lanzhou, Gansu 730000, China.
Abstract:
Osteoarthritis (OA) is the most common degenerative joint disease. Multiple tissues are altered during the development of OA, resulting in joint pain and permanent damage to the osteoarticular joints. Current research has demonstrated that non-apoptotic cell death plays a crucial role in OA. With the continuous development of targeted therapies, non-apoptotic cell death has shown great potential in the prevention and treatment of OA. We systematically reviewed research progress on the role of non-apoptotic cell death in the pathogenesis, development, and outcome of OA, including autophagy, pyroptosis, ferroptosis, necroptosis, immunogenic cell death, and parthanatos. This article reviews the mechanism of non-apoptotic cell death in OA and provides a theoretical basis for the identification of new targets for OA treatment.
Insights
Osteoarthritis (OA) involves various cell death types beyond apoptosis. Understanding these non-apoptotic cell death pathways offers new therapeutic targets for OA prevention and treatment.
Area of Science:
- Biomedical Science
- Orthopedics
- Cell Biology
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease causing pain and damage.
- Non-apoptotic cell death mechanisms are increasingly recognized as critical in OA pathogenesis.
Purpose of the Study:
- To systematically review the role of non-apoptotic cell death in OA.
- To explore mechanisms of autophagy, pyroptosis, ferroptosis, necroptosis, immunogenic cell death, and parthanatos in OA.
- To provide a theoretical basis for novel OA therapeutic targets.
Main Methods:
- Systematic literature review.
- Analysis of research progress on non-apoptotic cell death in OA.
- Review of OA pathogenesis, development, and outcomes related to cell death.
Main Results:
- Non-apoptotic cell death pathways significantly contribute to OA development and progression.
- Specific mechanisms of autophagy, pyroptosis, ferroptosis, necroptosis, ICD, and parthanatos are implicated in OA.
- These pathways represent potential targets for OA intervention.
Conclusions:
- Non-apoptotic cell death is a key factor in osteoarthritis.
- Targeting these cell death pathways holds promise for future OA treatments.
- Further research into these mechanisms can identify new therapeutic strategies for OA.
Related Concept Videos
01:30Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:30Apoptosis
01:19Mesenchymal Stem Cells
01:31Osteoclasts in Bone Remodeling