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Trabecular and cortical bone microarchitecture using high-resolution peripheral quantitative computed tomographic
Durairaj Arjunan1, Ashu Rastogi1, Jayaditya Ghosh1
1Dept. of Endocrinology, PGIMER, Chandigarh, 160012, India.
Diabetes & Metabolic Syndrome
|August 27, 2024
Summary
Type 2 Diabetes Mellitus (T2D) patients with peripheral neuropathy (PN) exhibit lower bone density and poorer bone structure. This highlights PN as a risk factor for skeletal fragility in T2D.
Area of Science:
- Endocrinology
- Orthopedics
- Bone Metabolism
Background:
- Type 2 Diabetes Mellitus (T2D) is linked to higher fragility fracture risk, even with normal bone mineral density (BMD).
- The impact of diabetic peripheral neuropathy (PN) on volumetric BMD (vBMD) and bone microarchitecture in T2D remains understudied.
Purpose of the Study:
- To evaluate vBMD and bone microarchitectural characteristics using high-resolution peripheral quantitative computed tomography (HR-pQCT).
- To compare these bone properties in T2D patients with and without PN.
Main Methods:
- A cross-sectional study involving 296 T2D patients, divided into T2D without PN (Group A, n=98) and T2D with PN (Group B, n=198).
- Clinical examination, biochemical analysis, DXA, and HR-pQCT of the radius and tibia were performed.
Main Results:
- HR-pQCT revealed significantly lower total and cortical vBMD at the tibia in Group B compared to Group A.
- Significant differences were observed in tibial cortical porosity, tibial trabecular number, and radial trabecular thickness between the groups.
Conclusions:
- T2D patients with PN demonstrate reduced vBMD and compromised skeletal microarchitecture compared to those without PN.
- These findings suggest PN contributes to skeletal deterioration in T2D, independent of areal BMD.
Keywords:
Bone microarchitectureBone mineral densityBone qualityCharcot's neuroarthropathyDiabetic neuropathyHigh resolutionPeripheral quantitative computed tomography (HR-pQCT)
