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Updated: Jun 15, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk

Chih-Chiang Hung1, Chung-Lin Tsai2, Yu-Ting Chin3,4

  • 1Division of Breast Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

Cancer Genomics & Proteomics
|August 27, 2024
PubMed
Abstract

Insights

Matrix metalloproteinase-2 (MMP-2) gene variants rs243865 and rs2285053 do not significantly impact breast cancer (BC) risk. These MMP-2 genotypes show a minimal effect on individual susceptibility to BC or triple-negative breast cancer (TNBC).

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Matrix metalloproteinase-2 (MMP-2) is linked to breast cancer (BC) pathogenesis.
  • Limited research exists on the association between MMP-2 genotypes and BC risk.

Purpose of the Study:

  • To investigate the relationship between MMP-2 promoter polymorphisms (rs243865 and rs2285053) and breast cancer risk.
  • To explore the impact of these genotypes on triple-negative breast cancer (TNBC) susceptibility.

Main Methods:

  • Genotyping of MMP-2 rs243865 and rs2285053 using PCR-based RFLP.
  • Analysis of a cohort including 1,232 breast cancer cases and 1,232 controls.

Main Results:

  • No significant differences in genotype distributions of rs243865 and rs2285053 between BC cases and controls.
  • Variant genotypes and alleles showed a non-significant trend towards decreased BC risk.
  • No significant associations were found between MMP-2 genotypes and TNBC risk.

Conclusions:

  • MMP-2 rs243865 and rs2285053 genotypes have a minimal impact on breast cancer susceptibility.
  • These specific MMP-2 polymorphisms do not appear to influence individual risk for BC or TNBC.
Keywords:
Breast cancergenotypematrix metalloproteinase-2polymorphismtriple negative breast cancer

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