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Gastric acid secretory function in preterm infants.

P E Hyman, D D Clarke, S L Everett

    The Journal of Pediatrics
    |March 1, 1985
    PubMed
    Summary
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    This study establishes normal gastric acid secretion values for preterm infants, showing acid output increases significantly in the first four weeks of life. These findings confirm a protective gastric pH barrier in most healthy preterm infants.

    Area of Science:

    • Neonatal Physiology
    • Gastrointestinal Function
    • Pediatric Gastroenterology

    Background:

    • Preterm infants often have immature gastrointestinal systems.
    • Understanding gastric secretory function is crucial for infant health.
    • Establishing normal values aids in assessing preterm infant development.

    Purpose of the Study:

    • To determine normal gastric acid output in healthy preterm infants.
    • To track changes in gastric secretory function during early life.
    • To correlate gastric pH with protective barriers against pathogens.

    Main Methods:

    • Longitudinal study of 34 healthy preterm infants.
    • Weekly measurements of basal and pentagastrin-stimulated acid output.
    • Assays for fasting serum gastrin and pancreatic polypeptide levels.

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    Main Results:

    • Basal acid output increased from 12 to 30 mumol/kg/hr in the first 4 weeks.
    • Pentagastrin-stimulated acid output rose from 21 to 44 mumol/kg/hr in the first 4 weeks.
    • Gastric acid secretion stabilized after 4 weeks; serum gastrin doubled by 2 months.

    Conclusions:

    • Healthy preterm infants achieve sufficient acid secretion for gastric pH control.
    • Gastric acid provides a barrier against bacterial and protein antigen colonization.
    • Established normal values serve as a benchmark for preterm infant gastric function.