Serum trace elements show association with thyroperoxidase autoantibodies in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules
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View abstract on PubMed
Summary
This summary is machine-generated.This study found no significant link between serum trace elements and thyroid nodules in general adults. However, for TI-RADS-4 thyroid nodules with abnormal TPO-Ab, measuring Ca, Zn, and Mo is recommended.
Area Of Science
- Endocrinology
- Environmental Health
- Clinical Chemistry
Background
- Thyroid nodules (TN) are a growing global health concern with unclear links to trace element exposure.
- Previous studies on trace elements and TN risk have yielded inconclusive results, necessitating further investigation.
Purpose Of The Study
- To investigate the association between serum trace elements (Ca, Mg, V, Fe, Co, Cu, Zn, Se, Mn, Mo) and the risk of thyroid nodules in adults.
- To explore the relationship between trace elements and thyroid function markers, particularly in individuals with TI-RADS-4 nodules.
Main Methods
- A cross-sectional study involving 1282 Chinese adults, with 377 diagnosed with TN via ultrasound.
- Serum trace elements were quantified using inductively coupled plasma mass spectrometry; thyroid function was assessed via chemiluminescent microparticle immunoassay.
- Restricted cubic splines and Bayesian kernel machine regression models were employed to analyze associations, adjusting for confounders using propensity score matching.
Main Results
- No statistically significant association was found between serum trace element concentrations and the overall risk of thyroid nodules after adjusting for confounders.
- Thyroid function indicators (FT3, T4) increased with higher total trace element mixture levels.
- In TI-RADS-4 TN subjects, TPO-Ab levels rose with increasing trace element mixtures, with Ca, Zn, and Mo showing interactive positive effects on TPO-Ab.
Conclusions
- Serum trace element detection appears insignificant for general thyroid nodule risk assessment.
- For individuals with TI-RADS-4 thyroid nodules and abnormal TPO-Ab, measuring serum Ca, Zn, and Mo is advised.
- Further research is needed to fully elucidate the complex associations between trace elements and thyroid nodule development.
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