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Updated: Jun 15, 2025

A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture
Published on: August 11, 2014
The Application of Organoids in the Study of Antiviral Innate Immunity
Tong Wu1, Chunfu Zheng2, Xiaodong Zou3,4
1Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Abstract:
Antiviral innate immunity plays a critical role in the defense against viral infections, yet its complex interactions with viruses have been challenging to study using traditional models. Organoids, three-dimensional (3D) tissue-like structures derived from stem cells, have emerged as powerful tools for modeling human tissues and studying the complex interactions between viruses and the host innate immune system. This chapter summarizes relevant applications of organoids in antiviral innate immunity studies and provides detailed information and experimental procedures for using organoids to study antiviral innate immunity.
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