Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stimulants01:29

Stimulants

173
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
173
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

169
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
169
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

451
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
451
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.6K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.6K
Blind Procedures02:07

Blind Procedures

10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Pharmacovigilance01:19

Pharmacovigilance

795
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
795

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contrasting perspectives and applications of the Good Samaritan Overdose Prevention Law: insights from people who use and distribute drugs in Rhode Island.

Health & justice·2026
Same author

Healthcare provider approaches to managing the health harms of xylazine: A qualitative study.

Journal of substance use and addiction treatment·2026
Same author

Medication and Acute Care Use in Young Adults With Opioid Use Subject to Medicaid Prescription Caps.

JAMA health forum·2026
Same author

Intersectional HIV disparities among transgender Medicare beneficiaries of color.

AIDS (London, England)·2026
Same author

An initial exploration of the daily associations between opioid use and acute suicide risk: The role of posttraumatic stress symptoms.

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors·2026
Same author

Business and Service Provider Attitudes Towards Police Involvement in Overdose Response: A Cross-Sectional Survey in Rhode Island Overdose Hotspots.

Journal of community health·2026
Same journal

Identifying co-occurring neighbourhood environmental patterns and their association with health behaviours in a Dutch urban population at high cardiometabolic risk.

BMC public health·2026
Same journal

Microplastic contamination in drinking water sources and distribution networks of a Western City in Iran.

BMC public health·2026
Same journal

Assessment of Long-Lasting Insecticidal Net (LLIN) ownership, utilization, and associated barriers in malaria-endemic communities of Ethiopia.

BMC public health·2026
Same journal

Associations between intrinsic capacity, subjectively perceived environmental support and functional status among rural disabled older adults in China: guided by the healthy ageing framework.

BMC public health·2026
Same journal

Environmental injustice in the West Bank: a mixed-methods assessment using SDG-based indicators.

BMC public health·2026
Same journal

Investigating environmental heat exposure and its effects on maternal and fetal health in rural Northern Ghana (Physio-HeMAB Study): a study protocol for a cluster randomized trial.

BMC public health·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.2K

Preventing overdoses involving stimulants: the POINTS study protocol.

Jaclyn M W Hughto1,2,3,4, Josiah D Rich5,6,7, Patrick J A Kelly8

  • 1Department of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI, 02912, USA. Jaclyn_Hughto@Brown.edu.

BMC Public Health
|August 27, 2024
PubMed
Summary
This summary is machine-generated.

Illicit stimulant overdoses are rising, with fentanyl posing a significant risk. This study identifies overdose risk factors and develops community-based interventions for people who use stimulants (PWUS) in Massachusetts and Rhode Island.

Keywords:
CocaineCrackDrug checkingFentanylIntervention developmentMethamphetamineMixed methodsOpioidsOverdoseStimulants

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

9.6K

Related Experiment Videos

Last Updated: Jun 15, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.2K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

9.6K

Area of Science:

  • Public Health
  • Epidemiology
  • Substance Use Research

Background:

  • Illicit stimulant overdoses, including cocaine and methamphetamine, have increased in the U.S.
  • Fentanyl adulteration of stimulants is a major overdose risk factor, particularly in Massachusetts and Rhode Island.
  • Understanding drug use patterns and overdose prevention strategies among people who use stimulants (PWUS) is crucial.

Purpose of the Study:

  • Reduce stimulant and opioid-involved overdose deaths in disproportionately affected regions.
  • Identify risk and protective factors for overdose among PWUS.
  • Develop and implement locally tailored intervention strategies.

Main Methods:

  • Conduct mixed-methods research with people who use and distribute stimulants (PWUS and PWDD).
  • Perform drug checking to analyze fentanyl and adulterant presence in the stimulant supply.
  • Convene stakeholder working groups to contextualize findings and identify multilevel interventions.

Main Results:

  • The study will provide a comprehensive understanding of stimulant and opioid-involved overdose social epidemiology.
  • Community-derived intervention strategies will be identified.
  • Findings will inform scalable overdose prevention efforts.

Conclusions:

  • This research will yield crucial insights into overdose risks associated with stimulant use.
  • It will facilitate the development of practical, community-driven strategies to prevent fatal and non-fatal overdoses.
  • The study aims to support high-risk communities in Massachusetts and Rhode Island.