[Comparison of Blood Oxygen Saturation Detection Methods in Patients with Hyperleukocytic Acute Leukemia]

To investigate which indicator is more advantageous when using arterial oxygen saturation (SaO₂) and fingertip pulse oxygen saturation (SpO₂) for blood oxygen detection in patients with hyperleukocytic acute leukemia (HAL).

In this prospective research, the difference between SaO₂ and SpO₂ of 18 HAL patients (observation group) and 14 patients (control group), as well as the relationship between the difference and white blood cell (WBC) counts were analyzed.

SaO₂ was lower than SpO₂ in the observation group (P <0.05), and SpO₂-SaO₂ difference was positively correlated with WBC counts (r =0.47). However, there was no statistical difference between SaO₂ and SpO₂ in the control group. SaO₂ and PO₂ showed a downward trend with the prolongation of detection time after arterial blood was collected in the observation group, but there was no statistical difference. There was no downward trend of SaO₂ and PO₂ in the control group.

HAL patients have a phenomenon where SaO₂ is lower than SpO₂, that is pseudohypoxemia, and this phenomenon may be caused by excessive consumption of oxygen by the leukemia cells in vitro SpO₂ can be monitored bedside in real time and is non-invasive, it is a better way to detect the blood oxygen status of HAL patients.