[Correlation of CD4+/CD8+Ratio in Peripheral Blood with Prognosis of Mantle Cell Lymphoma]
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View abstract on PubMed
Summary
This summary is machine-generated.A low CD4+/CD8+ T lymphocyte ratio is linked to poorer outcomes in mantle cell lymphoma (MCL). This ratio can serve as a key indicator for assessing prognosis risk in MCL patients.
Area Of Science
- Immunology
- Hematology
- Oncology
Context
- Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma.
- T lymphocyte subsets play a role in immune regulation and cancer progression.
- Understanding prognostic factors is crucial for managing MCL.
Purpose
- To investigate the correlation between peripheral blood T lymphocyte subsets and overall survival (OS) in MCL patients.
- To identify T lymphocyte subsets as potential prognostic markers for MCL.
Summary
- Retrospective analysis of 55 MCL patients revealed that a decreased CD4+/CD8+ T lymphocyte ratio was common.
- Patients with a CD4+/CD8+ ratio > 0.6 exhibited longer overall survival.
- Multivariate analysis identified a CD4+/CD8+ ratio ≤ 0.6 as an independent adverse prognostic factor for OS in MCL.
Impact
- The CD4+/CD8+ T lymphocyte ratio can be utilized as a valuable indicator for evaluating prognosis risk in MCL patients.
- This finding may contribute to improved risk stratification and personalized treatment strategies for MCL.
Keywords:
mantle cell lymphoma; CD4
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