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Updated: Jun 15, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Post-COVID Interstitial Lung Disease: How do We Deal with This New Entity?
Aycan Yüksel1, Dilek Karadoğan2, Nur Hürsoy3
1Department of Respiratory Medicine, Başkent University Faculty of Medicine, Ankara, Türkiye
Post-COVID interstitial lung disease (ILD) affects many survivors, characterized by persistent symptoms and lung abnormalities. Active smoking and severe COVID-19 are key risk factors, though some patients show spontaneous improvement.
Area of Science:
- Pulmonology
- Radiology
- Infectious Diseases
Background:
- Coronavirus disease-2019 (COVID-19) survivors may experience persistent symptoms and lung abnormalities post-recovery.
- This condition is termed post-COVID interstitial lung disease (ILD) or residual disease.
Purpose of the Study:
- To evaluate the characteristics, risk factors, and clinical significance of post-COVID ILD.
- To define diagnostic criteria for post-COVID ILD.
Main Methods:
- Multicenter cross-sectional analysis of data from a randomized clinical study.
- Patients with persistent respiratory symptoms 3 months post-COVID-19 were assessed.
- Post-COVID ILD defined by symptoms, hypoxemia, restrictive lung function, and HRCT findings.
Main Results:
- 262 out of 375 patients met criteria for post-COVID ILD.
- Dyspnea, exercise intolerance, and fatigue were common symptoms.
- Ground glass opacities and fibrotic bands were frequent HRCT findings.
- Active smoking, ICU admission, and elevated LDH were risk factors for post-COVID ILD.
Conclusions:
- Post-COVID ILD is characterized by respiratory symptoms, radiological lesions, and restrictive lung defects.
- Active smoking, severe COVID-19, and elevated LDH are significant risk factors.
- Approximately 20% of patients experience spontaneous improvement in symptoms and radiological findings.
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