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Photoluminescence: Applications

Photoluminescence: Applications

Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

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Toward Accurate Photoluminescence Nanothermometry Using Rare-Earth Doped Nanoparticles for Biomedical Applications.

Miao Liu¹, Jinyang Liang¹, Fiorenzo Vetrone¹

¹Centre Énergie Matériaux Télécommunications, Institut National de la Recherche Scientifique, Université du Québec, 1650 boulevard Lionel-Boulet, Varennes, Québec J3X 1P7, Canada.

Accounts of Chemical Research

|August 28, 2024

Summary

Rare-earth doped nanoparticles (RENPs) offer advanced photoluminescence nanothermometry for precise temperature sensing in biomedicine. Lifetime-based methods show promise despite current instrumentation challenges.

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Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science
Optical Physics

Background:

Photoluminescence nanothermometry enables submicrometer-scale temperature detection with minimal invasiveness, crucial for biomedical applications.
Rare-earth doped nanoparticles (RENPs) are advanced optical probes with unique properties like high photostability, tunable lifetimes, and multicolor emissions, making them ideal for nanothermometry.
RENPs offer advantages over other probes, including excitation with a single NIR wavelength, crucial for biological compatibility.

Purpose of the Study:

To provide a comprehensive overview of RENP-based photoluminescence nanothermometry.
To examine the architectures and luminescence mechanisms of RENPs.
To critically discuss the principles, techniques, applications, strengths, and limitations of photoluminescence intensity ratio (PLIR) and lifetime-based nanothermometry.

Main Methods:

Review and analysis of existing literature on RENP nanothermometry.
Examination of the fundamental principles of photoluminescence intensity ratio (PLIR) and lifetime-based nanothermometry.
Discussion of the architectural designs and luminescence mechanisms of RENPs.

Main Results:

RENPs exhibit versatile optical properties suitable for high-resolution temperature sensing.
PLIR nanothermometry is widely used but faces challenges with calibration and intensity fluctuations.
Lifetime-based nanothermometry offers greater robustness against experimental variations but requires advanced instrumentation.

Conclusions:

RENPs are highly promising for biomedical nanothermometry, with ongoing advancements in their design and application.
Lifetime-based nanothermometry is an emerging and critical area with significant potential for improved temperature sensing accuracy.
Further development in instrumentation and data analysis is needed to fully realize the potential of lifetime-based nanothermometry.