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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Impact of Diabetes on COVID-19 Susceptibility: A Nationwide Propensity Score Matching Study

Han Na Jang1, Sun Joon Moon1,2, Jin Hyung Jung3

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|August 28, 2024
PubMed

Insights

Individuals with diabetes have a higher risk of contracting coronavirus disease 2019 (COVID-19). This study found that diabetes significantly increases susceptibility to COVID-19 infection, necessitating enhanced preventive measures.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Endocrinology

Background:

  • Previous studies indicate poor clinical outcomes for patients with diabetes who contract COVID-19.
  • The susceptibility of individuals with diabetes to initial COVID-19 infection remains less understood.

Purpose of the Study:

  • To investigate the association between diabetes and the risk of COVID-19 infection.
  • To determine if diabetes increases susceptibility to SARS-CoV-2.

Main Methods:

  • Analysis of a large cohort (29,433 participants) from South Korea's National Health Insurance Service data.
  • Utilized 1:1 propensity score matching to compare individuals with and without diabetes.
  • Employed logistic regression to assess the risk of COVID-19 positivity.

Main Results:

  • COVID-19 positivity was significantly higher in participants with diabetes (3.5%) compared to those without (2.7%).
  • Diabetes was found to significantly increase the risk of testing positive for COVID-19 (OR, 1.307; P<0.001).
  • Patients with diabetes demonstrated heightened infection rates, indicating increased susceptibility.

Conclusions:

  • Diabetes mellitus is associated with a significantly higher risk of COVID-19 infection.
  • The findings underscore the importance of implementing stringent preventive strategies for individuals with diabetes.
  • Heightened vigilance is crucial, especially given the known adverse clinical outcomes in this population.

Keywords:
Angiotensin-converting enzymeCOVID-19Diabetes mellitus, type 2EpidemiologyInfections

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