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Observation of a positive interference in LC-MS/MS measurement of d6-25-OH-vitamin D3

Danielle Fortuna1, Warren R Korn1, Matthew J Brune1

  • 1Jefferson University Hospital, Philadelphia, PA, USA.

Clinical Mass Spectrometry (Del Mar, Calif.)
|August 28, 2024
PubMed
Abstract

No abstract available in PubMed .

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Interference leads to systematic error in atomic absorption (AA) measurements by enhancing or diminishing the analytical signal or the background. These interferences can be grouped into three main categories: spectral interference, chemical interference, and physical interference.
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