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Comparing ceramic Fischer-Koch-S and gyroid TPMS scaffolds for potential in bone tissue engineering
Vail Baumer1, Nelson Isaacson1, Shashank Kanakamedala1
1Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Frontiers in Bioengineering and Biotechnology
|August 28, 2024
Summary
Ceramic Fischer-Koch-S (FKS) scaffolds show superior strength and energy absorption compared to Gyroid scaffolds for bone tissue engineering. FKS scaffolds offer a promising alternative for bone regeneration applications prioritizing strength.
Area of Science:
- Biomaterials Science
- Biomedical Engineering
- Materials Science
Background:
- Triply Periodic Minimal Surfaces (TPMS) like Gyroid are used in bone tissue engineering (BTE) for their porous structures.
- Fischer-Koch-S (FKS) topology is suggested for bone scaffolds but underexplored experimentally.
- Ceramic fabrication of FKS scaffolds for BTE is novel.
Purpose of the Study:
- To fabricate ceramic Fischer-Koch-S (FKS) scaffolds for bone tissue engineering.
- To compare the mechanical properties and permeability of FKS scaffolds against Gyroid scaffolds.
- To evaluate the potential of FKS scaffolds for bone regeneration.
Main Methods:
- Fabrication of ceramic FKS and Gyroid scaffolds at 70% porosity.
- Mechanical testing to determine compressive strength and energy absorption.
- Permeability measurements and Weibull analysis for reliability.
- Scanning electron microscopy (SEM) for fracture analysis.
Main Results:
- FKS scaffolds were 32% stronger and absorbed 49% more energy than Gyroid scaffolds.
- FKS scaffolds exhibited 11% lower permeability than Gyroid scaffolds.
- Both topologies showed strength and permeability comparable to trabecular bone with high reliability.
Conclusions:
- Ceramic FKS scaffolds demonstrate enhanced mechanical performance over Gyroid scaffolds for BTE.
- FKS scaffolds are a promising candidate for bone regeneration, particularly where strength and reliability are prioritized.
- FKS scaffolds offer a viable alternative to Gyroid for specific BTE applications requiring higher structural integrity.
