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Related Experiment Videos

Spurious thrombocytopenia during pregnancy.

D L Solanki, B C Blackburn

    Obstetrics and Gynecology
    |March 1, 1985
    PubMed
    Summary

    Spurious thrombocytopenia in pregnant women can be caused by lab artifacts like platelet clumping or adherence to granulocytes. A blood smear review is crucial to avoid misdiagnosis and unnecessary interventions.

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    Area of Science:

    • Hematology
    • Obstetrics
    • Clinical Pathology

    Background:

    • Thrombocytopenia, a low platelet count, can indicate serious conditions during pregnancy.
    • Accurate diagnosis is vital for appropriate maternal and infant care.

    Observation:

    • Four healthy pregnant women presented with apparent thrombocytopenia.
    • The condition was identified as a laboratory artifact, not a true clinical issue.

    Findings:

    • In vitro platelet clumping or adherence to granulocytes in blood samples containing edetic acid caused the spurious thrombocytopenia.
    • One newborn transiently showed in vitro platelet clumping, likely due to maternal antibody transfer.

    Implications:

    • Recognizing these laboratory artifacts prevents unnecessary investigations and interventions.
    • Peripheral blood smear examination is essential for diagnosing true thrombocytopenia and avoiding management errors.

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