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Fatty Liver Disease Along Cushing Syndrome Evolution.
Maria Marengo1, Claire Briet1,2, Mathilde Munier1,2,3
1Department of Endocrinology, Diabetology and Nutrition, Angers University Hospital, 49100 Angers, France.
The Journal of Clinical Endocrinology and Metabolism
|August 28, 2024
Summary
Cushing syndrome often presents with metabolic syndrome and hepatic steatosis. This study found 26.5% of patients had metabolic dysfunction-associated steatotic liver disease (MASLD) at diagnosis, linked to diabetes and high triglycerides.
Area of Science:
- Endocrinology
- Hepatology
- Metabolic Syndrome
Background:
- Cushing syndrome frequently co-occurs with metabolic syndrome.
- Metabolic syndrome is strongly linked to hepatic steatosis, a key component of metabolic dysfunction-associated steatotic liver disease (MASLD).
Purpose of the Study:
- To determine the prevalence of MASLD at the time of Cushing syndrome diagnosis.
- To investigate the association between metabolic factors and MASLD in Cushing syndrome patients.
Main Methods:
- Retrospective single-center study of 49 Cushing syndrome patients with abdominal imaging.
- Hepatic steatosis diagnosed via liver/spleen density ratio on CT scan.
- Fibrosis predictive scores (FIB-4, NAFLD Fibrosis Score, eLIFT) calculated for patients with steatosis.
Main Results:
- Hepatic steatosis, diagnosed as MASLD, was present in 13 (26.5%) patients at Cushing syndrome diagnosis.
- MASLD patients exhibited higher rates of type 2 diabetes and elevated triglycerides.
- Two patients (15.4%) with MASLD showed scores predictive of significant fibrosis; 3/4 experienced steatosis remission after Cushing syndrome treatment.
Conclusions:
- The prevalence of hepatic steatosis (MASLD) at Cushing syndrome diagnosis is estimated at 26.5%.
- Metabolic factors are significantly associated with the development of hepatic steatosis in Cushing syndrome.
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