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Updated: Jun 15, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Published on: March 11, 2021

Criteria for Re-Irradiation.

Jonas Willmann¹, Nicolaus Andratschke, Jens Peter Klußmann

¹Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany; Rechts der Isar Medical Center, Department of Urology, Technical University Munich, Munich, Germany; Department of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, Center for Neuro-Oncology, Comprehensive Cancer Center, University Hospital Tübingen, Tubingen, Germany; Universitätsklinik für Radioonkologie, Universitätsklinikum Tübingen, Germany; Center for Neurooncology, Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.

Deutsches Arzteblatt International

|August 28, 2024

Summary

This summary is machine-generated.

Re-irradiation offers a treatment option for select cancer patients with progressive tumors. Evidence is limited, emphasizing the need for multidisciplinary collaboration in decision-making for re-irradiation therapy.

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Area of Science:

Oncology
Radiation Oncology
Cancer Therapeutics

Background:

Limited treatment options exist for progressive malignant tumors post-radiotherapy.
Re-irradiation is a viable option for selected cancer patients.
This review focuses on selection criteria and outcomes of re-irradiation for specific cancers.

Purpose of the Study:

To review the selection criteria for re-irradiation in cancer treatment.
To evaluate the outcomes and side effects of re-irradiation for specific tumor types.
To highlight the current evidence limitations and the importance of collaborative decision-making.

Main Methods:

Selective literature search in PubMed.
Focus on glioblastoma, head and neck tumors, and prostatic carcinoma.
Analysis of published studies, including randomized controlled trials (RCTs) where available.

Main Results:

Re-irradiation studies are scarce and often methodologically limited.
For glioblastoma, re-irradiation with bevacizumab showed no significant survival benefit.
For head and neck cancers, re-irradiation is an option but carries risks; hyperfractionated re-irradiation is superior for nasopharyngeal carcinoma.
Re-irradiation for prostate cancer shows promising oncologic outcomes with acceptable side effects compared to salvage prostatectomy.

Conclusions:

Re-irradiation is a valuable treatment modality for carefully selected cancer patients.
The limited scientific evidence necessitates multidisciplinary team collaboration.
Shared decision-making between patients and clinicians is crucial for re-irradiation therapy.