Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling the Dynamics of Electric Field-Assisted Local Functionalization in Two-Dimensional Materials.

Materials (Basel, Switzerland)·2026
Same author

Associations Between Genetic Polymorphisms and Psychological Variables in Women With Fibromyalgia: A Cross-Sectional Study.

European journal of pain (London, England)·2025
Same author

Morphogenesis of Human Scalene Muscles Between Weeks 6 and 13 of Development: Anatomical Aspects and Clinical-Functional Relevance.

Clinical anatomy (New York, N.Y.)·2025
Same author

Real-world experience of barriers to diagnosis, early detection and disease management among migrants living with HIV in Spain: a qualitative study.

Annals of medicine·2025
Same author

DNA Salivary Methylation Levels of the ACE2 Promoter Are Not Related to ACE2 (<i>rs2285666</i> and <i>rs2074192</i>), TMPRSS2 (<i>rs12329760</i> and <i>rs2070788</i>) and ACE1 <i>rs1799752</i> Polymorphisms in COVID-19 Survivors with Post-COVID-19 Condition.

International journal of molecular sciences·2025
Same author

Post-COVID-19 Pain Is Not Associated with DNA Methylation Levels of the <i>ACE2</i> Promoter in COVID-19 Survivors Hospitalized Due to SARS-CoV-2 Infection.

Biomedicines·2024

Related Experiment Video

Updated: Jun 15, 2025

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

5.7K

An Experimental Murine Model to Study Lipoatrophia Semicircularis.

María Angustias Palomar-Gallego1,2, Julio Ramiro-Bargueño3, Esther Cuerda-Galindo4

  • 1Department of Basic Health Sciences, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.

Current Issues in Molecular Biology
|August 28, 2024
PubMed
Summary

Electrostatic charges may cause lipoatrophia semicircularis (LS), a condition causing fat tissue loss. Grounding through skin exacerbated LS lesions in mice, suggesting a link between electrostatic discharge and fat tissue damage.

Keywords:
electrostatic energyfat tissuelipid peroxidationlipoatrophia semicircularis

More Related Videos

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.2K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.4K

Related Experiment Videos

Last Updated: Jun 15, 2025

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

5.7K
Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling
16:43

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

12.2K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.4K

Area of Science:

  • Dermatology
  • Biophysics
  • Pathology

Background:

  • Lipoatrophia semicircularis (LS) is a benign condition causing subcutaneous fat tissue atrophy.
  • The exact cause of LS is unknown, but electrostatic charges are a recent hypothesis.
  • Understanding the molecular mechanisms of LS is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the potential cause-effect relationship between electrostatic energy and lipoatrophia semicircularis.
  • To explore the molecular mechanisms underlying LS development due to electrostatic discharge.
  • To establish an experimental model for LS induced by electrostatic energy.

Main Methods:

  • An experimental murine model using obese mice was developed.
  • Mice were exposed to electrostatic charges with varying grounding methods (skin, clothing, none).
  • Skin biopsies and oxidative stress markers (malondialdehyde) were analyzed.

Main Results:

  • The most severe LS lesions, including lipophagic granulomas with inflammation, occurred when mice were grounded through the skin.
  • Electrostatic discharges induced lipophagic reactions without inflammation in other groups.
  • Electrostatic discharges increased malondialdehyde levels, indicating oxidative stress, but grounding reduced this effect.

Conclusions:

  • This study provides the first experimental evidence suggesting a cause-effect relationship between electrostatic charge/discharge and fat tissue lesions characteristic of LS.
  • Grounding through the skin appears to exacerbate LS development.
  • Electrostatic energy may play a significant role in the etiology of lipoatrophia semicircularis.