Related Experiment Video
Updated: Jun 15, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.7K
Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors?
Fabiana Amaral Guarienti1,2, Fernando Antônio Costa Xavier2,3,4, Mateus Duarte Ferraz2,3
1Post Graduation Program of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619, Brazil.
Current Issues in Molecular Biology
|August 28, 2024
Summary
Genetic variations in angiotensin-converting enzyme (ACE) and ACE2 may influence COVID-19 severity. Specific ACE and ACE2 intronic deletions were found in deceased patients, suggesting a link to mortality.
Area of Science:
- Genetics
- Virology
- Immunology
Background:
- The SARS-CoV-2 pandemic highlighted the need to understand disease mechanisms for future preparedness.
- Angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 entry, suggesting a role for ACE and ACE2 in infection severity.
- Significant variations in COVID-19 prognosis exist despite similar demographics and comorbidities.
Purpose of the Study:
- To investigate the role of angiotensin-converting enzyme (ACE) and ACE2 gene polymorphisms as predisposing factors in SARS-CoV-2 infection severity.
- To explore the association between specific genetic variations and COVID-19 outcomes.
Main Methods:
- Next-generation sequencing (NGS) was employed to analyze ACE and ACE2 genes.
- A sample group of six SARS-CoV-2 infected individuals was studied.
Main Results:
- Specific genetic polymorphisms in ACE and ACE2 were correlated with COVID-19 outcomes.
- Intronic deletions in both ACE and ACE2 genes were identified in all deceased patients in the study cohort.
- These findings suggest a potential association between these polymorphisms and mortality risk.
Conclusions:
- Genetic factors, particularly ACE and ACE2 polymorphisms, play a significant role in determining the clinical course and severity of COVID-19.
- Further research into the impact of genetic variations on COVID-19 is warranted to understand disease progression and inform potential interventions.
More Related Videos
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
14.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.9K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
510
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
510
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
404
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
404
02:28Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
02:50Conjugated Proteins
18.2K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.2K