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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Physical Methods for Controlling Microbial Growth: Radiation and Filtration01:26

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

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Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

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Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
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A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
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[Disinfection for dermatomycoses in veterinary practice].

A Rybnikár, V Vrzal, J Chumela

    Veterinarni Medicina
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study tested disinfectants against common dermatophytes. Peracetic acid, formaldehyde, and Lastanox super showed rapid antifungal effects, inactivating strains within minutes.

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    Area of Science:

    • Mycology
    • Dermatology
    • Infectious Diseases

    Background:

    • Dermatophytes are fungi causing skin infections.
    • Effective disinfection is crucial for preventing fungal transmission.

    Purpose of the Study:

    • To evaluate the efficacy of ten common disinfectants against dermatophyte strains.
    • To determine the minimum contact time and concentration for disinfectant activity.

    Main Methods:

    • Sporulating cultures of Trichophyton equinum, Trichophyton mentagrophytes, and Microsporum canis were used.
    • A simple dipping technique assessed sensitivity to disinfectants.
    • Disinfectants were tested at various concentrations and contact times.

    Main Results:

    • One-minute exposure to 0.5%-4% peracetic acid, 4% formaldehyde, and concentrated Lastanox super demonstrated antifungal effects.
    • Five-minute exposure to 1%-2% formaldehyde, 20% Iodonal B, and 10% active Ajatin inactivated all tested dermatophyte strains.
    • Other disinfectants exhibited varying degrees of fungistatic activity.

    Conclusions:

    • Peracetic acid, formaldehyde, and Lastanox super are effective disinfectants against common dermatophytes.
    • Specific concentrations and contact times are required for inactivation of these fungal pathogens.
    • Disinfectant choice should consider target pathogens and required efficacy.