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Correction: Ferreira-Reguera et al. Chitosan's Ability to Remove the Smear Layer-A Systematic Review of Ex Vivo Studies. <i>Medicina</i> 2025, <i>61</i>, 114.

Medicina (Kaunas, Lithuania)·2026
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The role of smoking as a risk indicator for apical periodontitis and endodontic status: a cross-sectional study of a portuguese adult sample.

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Impact of chronic alcohol consumption on inflammatory response and periapical bone resorption in induced apical periodontitis: a systematic review of animal studies.

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Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research.

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Related Experiment Video

Updated: Jun 15, 2025

Inducing Apical Periodontitis in Mice
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Osteoporosis and Apical Periodontitis Prevalence: A Systematic Review.

Natália Pestana de Vasconcelos1,2, Isabel Silva Martins1,2, Américo Santos Afonso3

  • 1Health Science Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal.

Dentistry Journal
|August 28, 2024
PubMed
Summary

This review found no strong evidence linking osteoporosis to a higher risk of apical periodontitis in adults. Further research is needed, but clinicians should consider potential impacts.

Keywords:
apical periodontitisbisphosphonatesbone densityendodonticspanoramic radiography

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Area of Science:

  • Oral Medicine
  • Endodontics
  • Bone Metabolism

Background:

  • Osteoporosis is a systemic bone disorder common in the elderly, marked by low bone density and structural deterioration.
  • Apical periodontitis involves inflammation and bone destruction around the tooth apex due to root canal infection.

Purpose of the Study:

  • To systematically review and determine if osteoporosis influences the prevalence of apical periodontitis in adults.

Main Methods:

  • Systematic review following PRISMA guidelines, searching PubMed, Scopus, and Web of Science until March 2024.
  • Included randomized clinical trials, cross-sectional, cohort, and case-control studies; assessed quality using the Newcastle-Ottawa Scale.
  • Analyzed three eligible studies (two cross-sectional, one case-control) with varying populations and methodologies.

Main Results:

  • Findings were inconsistent: one study suggested a marginal association, another a significant association, and a third found no link.
  • The study with the lowest risk of bias reported no association between osteoporosis and apical periodontitis.
  • Limitations included a scarcity of eligible studies and their overall quality.

Conclusions:

  • Currently, there is no robust evidence indicating that osteoporosis increases the likelihood of developing apical periodontitis in adults.
  • Clinicians should maintain awareness of osteoporosis's potential influence on apical periodontitis development and progression.