Genetic Engineering and Innovative Cultivation Strategies for Enhancing the Lutein Production in Microalgae

Area of Science:

• Biotechnology
• Nutraceuticals
• Microalgal cultivation

Background:

• Carotenoids possess significant biological activities and pharmaceutical potential, making them essential nutraceuticals.
• Microalgae are sustainable sources of bioactive compounds like carotenoids.
• Currently, only astaxanthin and β-carotene are commercially produced from microalgae.

Purpose of the Study:

• To review advancements in genetic engineering and cultivation for enhanced microalgal lutein production.
• To explore methods for improving lutein yield in microalgae for pharmaceutical applications.

Main Methods:

• Genetic engineering techniques including random mutagenesis, CRISPR technology, and multi-omics approaches.
• Comparative analysis of innovative microalgal cultivation strategies.

Main Results:

• Genetic engineering and advanced cultivation methods show promise for increasing lutein production in microalgae.
• CRISPR technology and multi-omics offer precise tools for strain improvement.

Conclusions:

• Further research is needed to overcome challenges in cost-effective, large-scale production of microalgal carotenoids.
• Continued development of genetically engineered microalgae is crucial for pharmaceutical applications.