Photochemical direct alkylation of heteroarenes with alkanes, alcohols, amides, and ethers

Direct functionalization of heteroarenes with simple alkanes utilizing anthracene as a photoredox catalyst has been established. This approach provides a sustainable alternative, avoiding costly reagents or peroxides. The method demonstrates a broad substrate scope, enabling regioselective alkylation of various heteroarenes, including azoles, pyridines, quinolines, isoquinolones, and quinoxalinones under mild conditions. A range of alkyl sources, such as alkanes, ethers, dioxane, trioxane, alcohol, and alkylamides were viable substrates. A plausible catalytic cycle was proposed based on the preliminary mechanistic evidence.