Related Experiment Video

Updated: Jun 15, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

Is disrupting cardiac fibrosis a rational strategy for treating heart disease?

Akitoshi Hara1, Michelle D Tallquist2

  • 1Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii, USA.

Nature Cardiovascular Research
|August 28, 2024
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K
Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
07:10

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

4.6K

Related Experiment Videos

Last Updated: Jun 15, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K
Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
07:10

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

4.6K

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

404
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
404
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

545
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
545

Articles linked to this work by shared authors, journal, and citation graph.

Evaluation of Alysis-001 cuffless blood pressure estimation algorithm against the European Society of Hypertension awake/asleep test criteria in hypertensive patients.

Hypertension research : official journal of the Japanese Society of Hypertension·2026

Advancing Geriatric Care in Japan: Integrating the 5Ms Framework With Comprehensive Geriatric Assessment for Enhanced Clinical Practice in a Super-Aged Society.

Geriatrics & gerontology international·2026

Protocol for quantitative live-cell imaging of early GPCR trafficking using acid-stable afCFP-Venus FRET.

STAR protocols·2026

Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling.

GeroScience·2026

Meflin/ISLR is a meningeal cell-specific marker involved in the development of meninges and meningioma progression.

Brain pathology (Zurich, Switzerland)·2025

Ikigai in aging hearts: Japan's approach to cardiovascular care.

Hypertension research : official journal of the Japanese Society of Hypertension·2025

Risk-guided cardioprotection in cardio-oncology.

Nature cardiovascular research·2026

Age-associated loss of lymphatic vessels promotes cardiac inflammation.

Nature cardiovascular research·2026

Spatially guided in vivo single-cell functional genomics of postnatal heart.

Nature cardiovascular research·2026

Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis.

Nature cardiovascular research·2026

Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.

Nature cardiovascular research·2026

A multiancestry polygenic risk score improves stratification in patients with hypertrophic cardiomyopathy.

Nature cardiovascular research·2026

Enzyme replacement therapy (ERT) combined with transient low-dose methotrexate (TLD-MTX) results in age- and disease-dependent immune profile changes in Infantile- vs. late-onset Pompe disease patients.

Frontiers in immunology·2026

Mitochondria-Targeted Nanozyme Reprograms Dendritic-Cell Immunometabolism via Microenvironment-Responsive CO Release to Treat Periodontitis.

Advanced healthcare materials·2026

Microaneurysm segmentation in early diabetic retinopathy: a localized patch-based U-Net approach to overcome microscopic lesion oversight.

International journal of retina and vitreous·2026

Routine microaxial left ventricular support during nonemergent high-risk PCI: an updated systematic review and meta-analysis with Bayesian and grade methodologies.

Expert review of medical devices·2026

Modified Hu-lu-ba-wan and its active component trigonelline ameliorate diabetic renal tubular injury via enhancing PACS2-regulated mitochondria-endoplasmic reticulum contacts and mitophagy.

Fitoterapia·2026

Electrophysiological Remodeling in Chronic Mitral Regurgitation: Underlying Substrates for Atrial Fibrillation.

The Journal of thoracic and cardiovascular surgery·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us