Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphatic invasion in Spitz nevi.

A J Howat, S Variend

    The American Journal of Surgical Pathology
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Vascular invasion in pediatric Spitz nevi is common, found in 14.3% of cases. This lymphatic invasion should not be misdiagnosed as melanoma, as patients recover well after treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Morphoea with prominent plasma cell endoneuritis.

    Clinical and experimental dermatology·2017
    Same author

    Myoepithelial cells in invasive breast carcinoma: a word of caution.

    Journal of clinical pathology·2011
    Same author

    Lymphoid tissue in the breast: a histological conundrum.

    Histopathology·2007
    Same author

    Pleomorphic spindle cells and hyperchromatic crowded groups in a cervical smear.

    Cytopathology : official journal of the British Society for Clinical Cytology·2006
    Same author

    Small-cell neuroendocrine carcinoma of the breast.

    Journal of clinical pathology·2006
    Same author

    Palisaded neutrophilic and granulomatous dermatitis.

    Clinical and experimental dermatology·2005

    Area of Science:

    • Dermatopathology
    • Pediatric Pathology

    Background:

    • Spitz nevi are benign skin tumors often seen in children.
    • Vascular invasion in Spitz nevi can be a diagnostic challenge, potentially mimicking melanoma.

    Purpose of the Study:

    • To determine the incidence of vascular invasion in pediatric Spitz nevi.
    • To evaluate the nature of vascular invasion (lymphatic vs. blood vessel) in these lesions.
    • To assess the clinical significance and patient outcomes associated with vascular invasion in Spitz nevi.

    Main Methods:

    • Retrospective review of 49 pediatric Spitz nevi.
    • Extensive histological sampling of each lesion.
    • Immunoperoxidase staining for Factor VIII-related antigen to differentiate vessel types.

    Related Experiment Videos

    Main Results:

    • Vascular invasion was identified in 7 out of 49 (14.3%) cases.
    • Endothelial staining for Factor VIII-related antigen was negative, indicating lymphatic channels.
    • No unusual histological or clinical features were noted in the affected cases.

    Conclusions:

    • Lymphatic invasion by nevus cells in Spitz nevi is relatively common.
    • The presence of lymphatic invasion does not necessitate a diagnosis of melanoma.
    • Pediatric Spitz nevi with lymphatic invasion have favorable outcomes following local excision.