Related Experiment Video

Updated: Jun 15, 2025

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Published on: May 24, 2016

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Toward drug-induced heart regeneration

Xuejun Yuan1,2,3, Thomas Braun4,5,6

  • 1Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Nature Cardiovascular Research
|August 28, 2024
PubMed
Summary

No abstract available in PubMed .

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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