Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

300
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
300
Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

181
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
181
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

29
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
29

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026
Same author

Clofarabine for relapsed/refractory Langerhans cell (LC) and non-LC histiocytosis.

Blood advances·2026
Same author

STING-STAT3-SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Growth Disturbances in Children With Rheumatologic Diseases.

Pediatric annals·2026
Same author

Growth Faltering: Definitions and References for Typical Ranges.

Pediatric annals·2026
Same author

Clinical relevance of mosaic variants detected by exome sequencing.

The Journal of allergy and clinical immunology·2026

Related Experiment Video

Updated: Jun 15, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.0K

Successful Management of Febrile Infection-Related Epilepsy Syndrome Using Cytokine-Directed Therapy.

Dana B Harrar1, Ilyse Genser1, Mejdi Najjar1

  • 1Division of Neurology, Children's National Hospital, Washington, DC, USA.

Journal of Child Neurology
|August 28, 2024
PubMed
Summary

This study presents a pediatric case of febrile infection-related epilepsy syndrome successfully treated with early cytokine-directed immunotherapy and avoiding barbiturate coma, leading to good neurologic and functional outcomes.

Keywords:
cytokinesfebrile infection-related epilepsy syndromeimmunotherapyketaminepentobarbital

More Related Videos

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

4.8K
A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

2.7K

Related Experiment Videos

Last Updated: Jun 15, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.0K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

4.8K
A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

2.7K

Area of Science:

  • Pediatric Neurology
  • Immunology
  • Epileptology

Background:

  • Febrile infection-related epilepsy syndrome (FIRES) is a severe condition characterized by refractory status epilepticus.
  • Traditional treatments can have significant side effects, necessitating alternative therapeutic strategies.

Observation:

  • A 5-year-old male presented with fever followed by encephalopathy and super-refractory status epilepticus.
  • The patient exhibited a complex cytokine profile during the illness.

Findings:

  • Early and aggressive immunomodulatory therapy targeting the patient's cytokine profile was administered.
  • A seizure management strategy avoiding barbiturate coma, including ketogenic diet and antiseizure medications, was employed.
  • The patient achieved good functional and neurologic outcomes, attending mainstream school with controlled epilepsy and mild neurocognitive impairment.

Implications:

  • Cytokine-directed immunotherapy represents a promising therapeutic approach for pediatric FIRES.
  • Avoiding barbiturate coma may lead to better long-term neurodevelopmental outcomes in FIRES patients.
  • This case highlights the potential of personalized immunomodulatory treatments in severe pediatric epilepsy syndromes.