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Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Sumel Ashique1,2, Neeraj Mishra3, Shubhrajit Mantry4

  • 1Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, 713212, India. ashiquesumel007@gmail.com.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|August 28, 2024
PubMed

Insights

Oxidative imbalance drives difficult-to-treat inflammatory lung diseases by causing excessive reactive oxygen species (ROS) and cellular damage. New therapeutic targets are needed to combat this oxidative stress and improve patient outcomes.

Area of Science:

  • Pulmonary Medicine
  • Oxidative Stress Research
  • Inflammatory Diseases

Background:

  • Inflammatory lung diseases cause significant global mortality and disability.
  • Severe variants of conditions like emphysema, asthma, and COVID-19 lack effective treatments.
  • Oxidative imbalance is a key factor in developing challenging inflammatory lung conditions.

Purpose of the Study:

  • To highlight the role of oxidative imbalance in severe inflammatory lung disorders.
  • To explore the mechanisms linking reactive oxygen species (ROS) to lung tissue damage.
  • To identify potential therapeutic targets for oxidative stress-induced lung inflammation.

Main Methods:

  • Review of current literature on oxidative stress and inflammatory lung diseases.
  • Analysis of the pathways involved in ROS production and signaling.
  • Identification of molecular targets for therapeutic intervention.

Main Results:

  • Endogenous antioxidant systems are insufficient against induced ROS overproduction.
  • ROS triggers pro-inflammatory mediators, leading to tissue damage and worsened inflammation.
  • Increased ROS can cause DNA damage, apoptosis, and proto-oncogene activation.

Conclusions:

  • Oxidative stress is a critical mechanism in severe inflammatory lung diseases.
  • Targeting ROS pathways offers potential for novel therapeutic strategies.
  • Further research into these targets could lead to new treatments for intractable lung conditions.
Keywords:
BiochemicalInflammationLung disordersOxidative stressReactive oxygen speciesToxicity

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