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Advances in nucleic acid therapeutics: structures, delivery systems, and future perspectives in cancer treatment

Leqi Zhang1, Wenting Lou1, Jianwei Wang2,3

  • 1Department of Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.

Clinical and Experimental Medicine
|August 28, 2024
PubMed

Insights

Nucleic acid therapeutics offer promising cancer treatment options by regulating gene expression. Delivery vectors are crucial for enhancing stability and targeted delivery of these novel cancer drugs.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Oncology

Background:

  • Cancer remains a major global health challenge.
  • Nucleic acid therapeutics represent a novel approach to cancer treatment by modulating gene expression.
  • Challenges include poor stability and limited in vivo delivery of nucleic acid drugs.

Purpose of the Study:

  • To review the structures and mechanisms of nucleic acid drugs for cancer therapy.
  • To explore cellular uptake and intracellular transport of these therapeutics.
  • To highlight advancements in nucleic acid delivery vectors for cancer treatment.

Main Methods:

  • Literature review of nucleic acid drug structures and delivery systems.
  • Analysis of cellular mechanisms involved in nucleic acid drug action.
  • Evaluation of recent research progress and applications of delivery vectors.

Main Results:

  • Nucleic acid drugs show high specificity and potential for tumor remission.
  • Various delivery vectors have been developed to overcome stability and targeting limitations.
  • Recent research demonstrates significant progress in vector design and application.

Conclusions:

  • Nucleic acid therapeutics hold significant promise for cancer treatment.
  • Effective delivery vectors are essential for realizing the full therapeutic potential.
  • Future directions involve optimizing vectors for enhanced stability and targeted delivery.
Keywords:
Cancer therapyDrug deliveryGenetic vectorsNucleic acids

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