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MOF-Modified Microrollers for Bioimaging and Sustained Antibiotic Delivery.

Yukun Zhong1, Junkai Zhang1, Lijun Fang1

  • 1Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

ACS Applied Materials & Interfaces
|August 28, 2024
PubMed
Summary

New microrollers combat central nervous system (CNS) infections by delivering antibiotics. These biocompatible, magnetically actuated microrollers offer efficient drug delivery for treating CNS infections.

Keywords:
chicken embryo chorioallantoic membrane (CAM)magnetic controlmetal−organic framework (MOF)microrobotmicroroller

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Central nervous system (CNS) infections pose significant challenges, often arising from neurosurgery or contaminated cerebrospinal fluid.
  • Current drug-delivery systems struggle with efficient movement and sustained therapeutic release within the complex CNS environment.

Purpose of the Study:

  • To develop biocompatible, magnetically actuated microrollers (MMRs) for targeted antibacterial applications within the CNS.
  • To enhance MMRs' motion and drug-eluting capabilities for combating CNS infections.

Main Methods:

  • Fabrication of MMRs using metal-organic framework (MOF) NH2-MIL-101(Fe) with Fe/Al coating for magnetic actuation and biocompatibility.
  • Evaluation of MMR motion on simulated CNS tissue using an organ-on-a-chip model and computational fluid dynamics (CFD).
  • Loading MMRs with rhodamine 6G for bioimaging and tetracycline hydrochloride for antibiotic delivery against Staphylococcus aureus biofilms.

Main Results:

  • MMRs exhibited faster, unhindered magnetic actuation on uneven biological tissue surfaces compared to smooth surfaces, consistent with CFD findings.
  • Bioimaging demonstrated MMRs' visibility through human tissue sections via fluorescence microscopy.
  • Sustained release of tetracycline hydrochloride from MMRs inhibited Staphylococcus aureus biofilms for up to 9 days.

Conclusions:

  • The proposed MMRs offer a promising strategy for long-term, targeted antibacterial delivery in biological environments.
  • Integration of high-capacity adsorption materials with magnetic locomotion provides an effective approach for treating CNS infections.