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Versatility of OnabotulinumtoxinA in Aesthetic Medicine
Mitchell F Brin1,2, John Maltman1, Mary Ann Chapman3
1Allergan Aesthetics, An AbbVie Company, Irvine, California.
Background:
OnabotulinumtoxinA is an injectable product that was introduced into medicine in the 1970s and has been the subject of thousands of clinical and nonclinical publications.
Objective:
To review the data related to the versatility of onabotulinumtoxinA in medical aesthetics.
Methods:
PubMed was searched to identify literature evaluating the effects of onabotulinumtoxinA, with preference given to randomized, placebo-controlled trials and safety meta-analyses.
Results:
OnabotulinumtoxinA is effective and safe across multiple facial indications, racial and ethnic groups, age groups, genders, and facial line severities. Patient-reported outcomes have been prioritized in aesthetic clinical trials and indicate high patient satisfaction and appearance-related psychological outcomes. Integrated safety meta-analysis and immunogenicity analyses have documented acceptable adverse event rates and low immunogenicity of onabotulinumtoxinA.
Conclusion:
OnabotulinumtoxinA is a versatile aesthetic product supported by a strong literature base and positive physician and patient-reported outcomes that reflect a meaningful impact on patient's quality of life.
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