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Updated: Jun 15, 2025
07:05
Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
22.9K
Using Neuromodulators for Salivary, Eccrine, and Apocrine Gland Disorders
Susruthi Rajanala1, Nicole Salame2, Jeffrey S Dover3
1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Summary
Botulinum toxin treatments offer a safe and effective way to manage glandular disorders like sialorrhea and hyperhidrosis, improving patient quality of life. Further research is needed for optimal dosing in other conditions.
Area of Science:
- Investigates the dermatological and neurological applications of neuromodulators.
- Focuses on glandular disorders affecting quality of life.
Background:
- Sialorrhea, hyperhidrosis, bromhidrosis, and chromhidrosis are common glandular disorders impacting patient health and quality of life.
- Botulinum toxin temporarily reduces gland secretions by targeting parasympathetic cholinergic neurons, decreasing saliva and sweat production.
Purpose of the Study:
- To review the therapeutic applications of neuromodulators for salivary, eccrine, and apocrine glands.
- To synthesize current knowledge on botulinum toxin's efficacy in treating various hyperhidrosis and sialorrhea conditions.
Main Methods:
- Comprehensive literature search of PubMed from inception to February 1, 2024.
- Utilized search terms including "neurotoxin," "botulinum toxin," "sialorrhea," "hyperhidrosis," "bromhidrosis," and "chromhidrosis."
Main Results:
- Incobotulinumtoxin A and Rimabotulinumtoxin B are FDA-approved for sialorrhea treatment.
- Onabotulinumtoxin A is FDA-approved for axillary hyperhidrosis and used off-label for other hyperhidrosis, bromhidrosis, and chromhidrosis.
- Botulinum toxin serotype B shows higher immunogenicity compared to serotype A, impacting long-term treatment.
Conclusions:
- Neuromodulators provide a safe and effective noninvasive treatment for excessive gland activity, enhancing patient quality of life.
- While botulinum toxin is well-supported for hyperhidrosis, further research is required for standardized dosing and administration in sialorrhea, bromhidrosis, and chromhidrosis.
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