Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Photochemical Electrocyclic Reactions: Stereochemistry

Photochemical Electrocyclic Reactions: Stereochemistry

The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating LC-MS and network pharmacology to uncover the mechanism of antidepressant effects of Illigera aromatica ethanol extract in rodent models.

Fitoterapia·2026

Same author

Implantable venous access port catheter fracture in a severely obese lung cancer patient undergoing chemotherapy: a case report.

Frontiers in oncology·2026

Same author

[Effect of low light stress on growth and active ingredient content of Pinellia ternata].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Same author

Early Identification of Differentiation Syndrome During ATRA and Arsenic Therapy in Pediatric NHR-APL: Insights From a 14-Year Multicenter Cohort.

Pharmacoepidemiology and drug safety·2026

Same author

Mechanism-Driven Self-Powered Biosensing: Integrating Entropy-Controlled Nanocatalysis with Machine Learning on a Generalizable Hydrogel Platform.

Analytical chemistry·2026

Same author

DNAzyme-protease cascade amplified triple-modal biosensing platform with machine learning integration for specific monitoring of plant pathogens.

Biosensors & bioelectronics·2026

Search research articles

Related Experiment Video

Updated: Jun 15, 2025

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Target-Triggered Multiple-Polarity-Switchable Multiplexed Photoelectrochemical Platform.

Zi-Long Ma¹, Jia-Jie Chen², Xu-Fei Sun¹

¹Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission; Guangxi Key Laboratory of Chemistry and Engineering of Forest Products; Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products; Laboratory of Optic-electric Chemo/Biosensing and Molecular Recognition, Education Department of Guangxi Zhuang Autonomous Region. School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.

Analytical Chemistry

|August 28, 2024

Summary

This summary is machine-generated.

This study introduces a novel photoelectrochemical (PEC) sensor for simultaneous disease biomarker detection. The innovative polarity-switching mode enables sensitive and accurate multitarget quantification for community screening.

More Related Videos

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts

Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts

Published on: August 7, 2018

Related Experiment Videos

Last Updated: Jun 15, 2025

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts

Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts

Published on: August 7, 2018

Area of Science:

Electrochemistry
Biosensing
Nanotechnology

Background:

Accurate quantification of multiple disease biomarkers is crucial for effective community screening.
Photoelectrochemical (PEC) sensors offer potential for sensitive detection, but research on continuous multitarget detection using polarity-switching modes is limited.

Purpose of the Study:

To develop a multiplexed PEC bioassay utilizing a target-triggered "anodic-cathodic-anodic" polarity-switching mode for simultaneous detection of multiple analytes.
To demonstrate the sensor's capability using microRNA-21 (miRNA-21) and microRNA-141 (miRNA-141) as model targets.
To enhance the sensor's practical utility and affordability for community-based disease screening.

Main Methods:

A multiplexed PEC bioassay was designed based on a "anodic-cathodic-anodic" polarity-switching mechanism triggered by target binding.
Specific photosensitive material combinations (Cu2O/gold nanoparticles/TiO2 and CdS/gold nanoparticles/TiO2) were assembled using whisker-DNA and DNA ring structures.
The sensor incorporated a capacitor and a multimeter-smartphone connection to simplify assembly and reduce costs.

Main Results:

The PEC sensor achieved sensitive and selective quantification of miRNA-21 and miRNA-141.
Linear detection ranges were observed from 0.01 fM to 10 nM for both miRNA-21 and miRNA-141.
Ultra-low detection limits were achieved: 3.2 aM for miRNA-21 and 4.3 aM for miRNA-141.
The polarity-switching mode effectively reduced interference and enabled high-sensitivity detection.

Conclusions:

The developed target-triggered multiple-polarity-switchable PEC bioassay enables sensitive and accurate simultaneous detection of multiple disease biomarkers.
The sensor design is adaptable for detecting other multitargets by modifying DNA structures and photosensitive materials.
This approach holds significant promise for cost-effective and convenient community disease screening.