Functional liver imaging score (FLIS) can predict adverse events in HCC patients
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View abstract on PubMed
Summary
This summary is machine-generated.The Liver Imaging Function Score (FLIS) shows promise in predicting post-hepatectomy liver failure (PHLF) and death. This tool can help identify patients at higher risk before liver surgery for malignancies.
Area Of Science
- Radiology
- Hepatobiliary Surgery
- Oncology
Background
- Liver surgery for malignancies carries risks of post-hepatectomy liver failure (PHLF) and mortality.
- Accurate preoperative risk assessment is crucial for patient management and surgical planning.
Purpose Of The Study
- To evaluate the effectiveness of the Liver Imaging Function Score (FLIS) in predicting PHLF and overall survival (OS) after liver resection for malignancies.
Main Methods
- 150 patients undergoing liver resection with gadoxetetic acid-enhanced MRI were retrospectively analyzed.
- Two experienced radiologists assessed liver parenchymal enhancement, biliary excretion, and portal vein signal intensity.
- Cox regression and AUROC analyses were used to determine predictors of PHLF and OS.
Main Results
- FLIS was associated with adverse outcomes in the hepatocellular carcinoma (HCC) group (HR=1.891, p=0.039).
- The FLIS AUROC for predicting adverse outcomes was 0.660, with 87% sensitivity and 33.3% specificity.
- Post-surgical blood transfusions and major resection were significant predictors of adverse events in the overall population.
Conclusions
- FLIS is a potentially valuable tool for preoperative risk stratification of patients undergoing liver surgery.
- Identifying patients at risk of PHLF and death can guide clinical decision-making and improve outcomes.
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