Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and efficacy of ravulizumab in patients with NMOSD previously treated with rituximab: A post hoc analysis of the CHAMPION-NMOSD trial.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Same author

Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers.

Revue neurologique·2025

Same author

French guidelines for the diagnosis and management of MOG antibody-associated disease.

Revue neurologique·2025

Same author

A scoping review of visual communication of written patient health information preferences including a Māori perspective.

Health education research·2025

Same author

SUNCT onset following ophthalmic-distribution zoster: Description of a case and review of the literature.

Revue neurologique·2024

Same author

Clinical applications of deep learning in neuroinflammatory diseases: A scoping review.

Revue neurologique·2024

Search research articles

Related Experiment Video

Updated: May 8, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Teriflunomide, cognition and MRI: A longitudinal study.

L Pfaff¹, M Mondino², Q Loeb²

¹University of Strasbourg, Strasbourg, Biopathology of Myelin, Neuroprotection and Therapeutic Strategies, INSERM U1119, Strasbourg, France.

Multiple Sclerosis and Related Disorders

|August 28, 2024

Summary

Teriflunomide (TRF) treatment in relapsing-remitting multiple sclerosis (RRMS) improved long-term verbal memory and inhibition after two years. MRI data indicated a correlation between cognitive improvements and white matter volume changes, particularly in the corpus callosum.

Keywords:

Cognition MRI Teriflunomide Treatment

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

Related Experiment Videos

Last Updated: May 8, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Cognitive impairment is a common and disabling symptom in multiple sclerosis (MS).
Teriflunomide (TRF) is a disease-modifying therapy for MS, but its effects on cognition are not well-established.
Understanding TRF's impact on cognitive function and associated neuroimaging changes is crucial for MS management.

Purpose of the Study:

To investigate the influence of Teriflunomide (TRF) on comprehensive cognitive function in relapsing-remitting multiple sclerosis (RRMS).
To explore the correlations between cognitive performance and MRI-derived global and focal brain volumes after two years of TRF therapy.
To differentiate the effects of TRF on cognitive function in RRMS patients with and without baseline cognitive impairment.

Main Methods:

Twenty-four RRMS patients were assessed at baseline and after two years of TRF treatment.
Cognitive function was evaluated using the BCcogSEP battery, including the Selective Reminding Test (SRT) and GoNoGo task.
MRI data, including corpus callosum volume and Percentage Brain Volume Change, were correlated with cognitive test performance.

Main Results:

After two years, significant improvements were observed in SRT learning, delayed recall, and the GoNoGo task.
Corpus callosum volume positively correlated with SRT total recall performance.
Patients with cognitive impairment showed significant differences in white matter volume and Percentage Brain Volume Change compared to those without.

Conclusions:

Teriflunomide (TRF) treatment demonstrates a positive effect on cognitive function in RRMS, specifically enhancing long-term verbal memory and inhibition.
Neuroimaging findings suggest a link between cognitive improvements and changes in global and focal white matter volumes, notably the corpus callosum.
These results highlight the potential of TRF in addressing cognitive deficits in MS and underscore the role of white matter integrity in brain plasticity.