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Gentamicin-resistant Pseudomonas endophthalmitis after penetrating keratoplasty
The British Journal of Ophthalmology
|March 1, 1985
Abstract:
A case of pseudomonas endophthalmitis after penetrating keratoplasty is described. Bacterial sensitivities in this case and in five of six previously reported cases of endophthalmitis after corneal transplant showed resistance to gentamicin, an antibiotic routinely used in the transport medium. The recovery of antibiotic resistant bacteria in antibiotic supplemented media is discussed with emphasis on prevention.
Insights
Pseudomonas endophthalmitis after corneal transplants showed gentamicin resistance. This highlights the risk of antibiotic-resistant bacteria in transport media, emphasizing prevention strategies.
Area of Science:
- Ophthalmology
- Microbiology
Background:
- Penetrating keratoplasty is a common corneal transplant procedure.
- Endophthalmitis is a serious intraocular infection that can occur post-keratoplasty.
Observation:
- A case of Pseudomonas endophthalmitis following penetrating keratoplasty is presented.
- Bacterial cultures revealed Pseudomonas species resistant to gentamicin.
Findings:
- Five of six previously reported cases of post-keratoplasty endophthalmitis also showed gentamicin resistance.
- Gentamicin is frequently used in transport media for corneal tissue.
Implications:
- Routine use of gentamicin in transport media may contribute to the selection of antibiotic-resistant bacteria.
- This resistance poses a significant challenge to treating post-keratoplasty endophthalmitis.
- Revising transport media protocols and enhancing preventative measures are crucial.