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Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula

Wei-Jan Wang1, Hsuan-Ting Tang2, Shi-Chen Ou3

  • 1Department of Biological Science and Technology, China Medical University, Taichung, Taiwan; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.

Cancer Letters
|August 28, 2024
PubMed

Insights

The novel Kang Guan Recipe (KGR) herbal formula shows strong potential to inhibit SARS-CoV-2 infection. KGR blocks viral entry by preventing spike protein and ACE2 interaction, offering a new COVID-19 preventive strategy.

Area of Science:

  • Virology
  • Immunology
  • Herbal Medicine

Background:

  • COVID-19 remains a global health challenge with ongoing breakthrough infections.
  • Herbal medicines show promise in combating viral infections, including SARS-CoV-2.
  • Interest is growing in alternative preventive strategies like dietary and herbal interventions.

Purpose of the Study:

  • To investigate the inhibitory activity of the Kang Guan Recipe (KGR) against SARS-CoV-2.
  • To explore the mechanism by which KGR affects SARS-CoV-2 infection.
  • To assess the in vivo efficacy of KGR against SARS-CoV-2 variants.

Main Methods:

  • In vitro testing of KGR against SARS-CoV-2 variants of concern (VOCs).
  • Analysis of KGR's effect on the interaction between the SARS-CoV-2 spike protein and human ACE2.
  • In vivo assessment of KGR's inhibitory effect on viral entry using serum from KGR-treated human subjects.

Main Results:

  • KGR demonstrated potent inhibition against SARS-CoV-2 infection, including multiple VOCs.
  • KGR was found to block the interaction between the viral spike protein and ACE2.
  • Serum from KGR-treated individuals showed suppressive activity against SARS-CoV-2 variants in vivo.

Conclusions:

  • The Kang Guan Recipe (KGR) exhibits significant antiviral activity against SARS-CoV-2.
  • KGR's mechanism involves blocking the spike protein-ACE2 interaction, a key step in viral entry.
  • KGR presents a promising herbal-based preventive and therapeutic option for COVID-19.
Keywords:
Angiotensin-converting enzyme 2Coronavirus disease 2019Kang guan recipeSevere acute respiratory syndrome coronavirus 2Variants of concern

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