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Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor

Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor

Ding Li ¹, Chen Ding ¹, Fan Huang ¹, Mengmeng Chang ¹, Zhiyi Lu ¹, Guowei Li ¹, Yingying Li ², Hongjie Gao ³, Fengyin Sun ⁴

Ding Li ¹, Chen Ding ¹, Fan Huang ¹

¹Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, P.R. China.
²Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, P.R. China.
³Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, P.R. China gaohongjie@qiluhospital.com.
⁴Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, P.R. China; f12cxgsb@163.com.

⁰Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, P.R. China.

Anticancer Research +

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August 28, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Plasminogen activator urokinase (PLAU) is a key immune gene in Wilms' tumor (WT). High PLAU expression indicates better survival, while low expression is linked to poor prognosis and potential epigenetic regulation.

Area Of Science

Oncology
Immunology
Molecular Biology

Background

Autophagy and immunity are crucial in malignant tumor growth and represent therapeutic targets.
Wilms' tumor (WT) is a pediatric kidney cancer where understanding immune gene involvement is vital.

Purpose Of The Study

To identify immune genes related to autophagy in WT.
To analyze the prognostic significance of these genes in WT patients.

Main Methods

Utilized public datasets (TCGA, ImmPort, GeneCards) for WT.
Screened differentially expressed immune genes associated with autophagy, identifying plasminogen activator urokinase (PLAU).
Performed survival analysis, Cox regression, GO, KEGG, GSEA, and analyzed immune cell infiltration and epigenetic modifications.

Main Results

PLAU expression is an independent prognostic indicator for overall survival (OS) in WT patients.
PLAU is implicated in RNA transcription and epithelial cell migration.
High PLAU expression correlates with increased antitumor immune cell infiltration; low expression is linked to DNA methylation and potential miR-342-3p co-regulation.

Conclusions

PLAU serves as a reliable independent prognostic biomarker for WT.
Low PLAU expression signifies a poorer prognosis in WT.
Understanding PLAU's prognostic value and associated pathways can guide novel WT therapeutic strategies.

Keywords:

PLAU gene Wilms’ tumor autophagy immune genes prognostic value

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