Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

347
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
347
Tumor Immunotherapy01:27

Tumor Immunotherapy

493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Evaluation of Immune Cell Therapy in Esophageal Cancer Resistant to Immunochemotherapy.

Anticancer research·2025
Same author

[A Case of Remarkable Immune-Cell Therapy Efficacy in a Patient with Renal Pelvic Cancer Refractory to Immune Checkpoint Inhibitors and Chemotherapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2025
Same author

A pilot study on the safety and efficacy of neoadjuvant chemo‑adoptive immunotherapy for locally advanced rectal cancer.

Oncology letters·2024
Same author

Effects of adoptive T-cell immunotherapy on immune cell profiles and prognosis of patients with unresectable or recurrent cholangiocarcinoma.

International journal of cancer·2023
Same author

Safety evaluation of immune-cell therapy for malignant tumor in the Cancer Immune-cell Therapy Evaluation Group (CITEG).

Cytotherapy·2023
Same author

Prospective study of adoptive activated αβT lymphocyte immunotherapy for refractory cancers: development and validation of a response scoring system.

Cytotherapy·2022

Related Experiment Video

Updated: Jun 15, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.8K

Personalized Dendritic-cell-based Vaccines Targeting Cancer Neoantigens.

Takashi Kamigaki1,2, Rishu Takimoto3,2,4, Sachiko Okada3,2

  • 1Next Generation Cell and Immunotherapy, Advanced Research Institute for Health Science, Juntendo University, Tokyo, Japan; kamigaki@j-immunother.com.

Anticancer Research
|August 28, 2024
PubMed
Summary

Cancer immunotherapy uses neoantigen vaccines to activate the immune system against tumors. Personalized dendritic-cell (DC)-based vaccines show promise for enhanced T cell responses and future cancer treatment strategies.

Keywords:
Dendritic cell vaccineneoantigenpersonalized vaccinereviewsolid tumor

More Related Videos

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

3.4K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.2K

Related Experiment Videos

Last Updated: Jun 15, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.8K
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

3.4K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.2K

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Cancer immunotherapy harnesses the host immune system to target tumor cells, offering novel treatment avenues.
  • Neoantigens, arising from tumor-specific mutations, elicit potent immune responses without inducing central immune tolerance.
  • Advances in neoantigen identification technologies are driving the development of neoantigen-focused vaccines.

Purpose of the Study:

  • To review the properties of neoantigens and the characteristics of dendritic cells (DCs).
  • To discuss the clinical applications of neoantigen vaccines, with a focus on personalized DC-based vaccines.
  • To explore future research directions and challenges in the field of neoantigen vaccines.

Main Methods:

  • Review of scientific literature on neoantigens, dendritic cells, and cancer vaccines.
  • Analysis of different neoantigen vaccine platforms, including synthetic long peptides, mRNA, and DC-based vaccines.
  • Discussion of the immunological mechanisms and clinical potential of personalized DC-based vaccines.

Main Results:

  • Neoantigens are critical targets for cancer immunotherapy due to their immunogenicity and tumor specificity.
  • Dendritic cells (DCs) are potent antigen-presenting cells capable of stimulating robust T cell responses.
  • Personalized DC-based vaccines offer a flexible platform for delivering neoantigens and have shown potential in eliciting strong anti-tumor immunity.

Conclusions:

  • Neoantigen vaccines, particularly personalized DC-based vaccines, represent a promising frontier in cancer treatment.
  • The ability of DCs to present diverse antigens, including neoantigens, makes them ideal candidates for vaccine development.
  • Further research and development are necessary to overcome challenges and fully realize the potential of neoantigen vaccines in clinical practice.