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Related Concept Videos

Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...

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Transjugular Transcatheter Tricuspid Valve Replacement: Early Compassionate Use Outcomes.

Lukas Stolz1, Anson Cheung2, Robert Boone2

  • 1Medizinische Klinik und Poliklinik I, Ludwig-Maximilians University Klinikum, Ludwig-Maximilians University München, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: https://twitter.com/stolz_l.

JACC. Cardiovascular Interventions
|August 28, 2024
PubMed
Summary
This summary is machine-generated.

Transjugular transcatheter tricuspid valve replacement (TTVR) is safe and effective for severe tricuspid regurgitation. Outcomes remain comparable even with large device sizes, offering a viable treatment option.

Keywords:
TTVITTVRtranscatheter tricuspid valve replacementtransjugulartricuspid regurgitation

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Area of Science:

  • Interventional Cardiology
  • Cardiovascular Surgery
  • Medical Device Technology

Background:

  • Limited data exists on procedural and early outcomes for transjugular transcatheter tricuspid valve replacement (TTVR).
  • Assessing TTVR efficacy, particularly with larger device sizes, is crucial for managing severe tricuspid regurgitation.

Purpose of the Study:

  • To evaluate the first-in-human procedural and clinical outcomes of transjugular TTVR.
  • To specifically assess outcomes in patients receiving large device sizes, where efficacy has been questioned.

Main Methods:

  • A retrospective registry of 76 patients undergoing TTVR with the LuX-Valve Plus system for symptomatic tricuspid regurgitation.
  • Data collected from January 2022 to February 2024 across 15 international centers.
  • Endpoints included procedural TR reduction, in-hospital mortality, adverse events, and 1-month survival, stratified by device size (≥55 mm vs. <55 mm).

Main Results:

  • Successful TR reduction to ≤1+ in 90.8% of patients, with 75% receiving devices ≥55 mm.
  • 1-month survival was 94.4%, with significant improvement in NYHA functional class.
  • Low rates of in-hospital death (5.3%), major bleeding (6.6%), and new pacemaker implantation (3.9%); no stroke or pulmonary embolism observed.
  • Outcomes were comparable between patients receiving small (<55 mm) and large (≥55 mm) devices.

Conclusions:

  • Transjugular TTVR demonstrates safety and effectiveness in treating severe tricuspid regurgitation.
  • The procedure shows comparable outcomes even in patients with very large tricuspid anatomies requiring larger devices.